Considerations With Orthopedic Surgery in EDS Patients

Orthopedic Considerations and Surgical Outcomes in Ehlers–Danlos Syndromes https://pubmed.ncbi.nlm.nih.gov/34845816/
Yonko EA, LoTurco HM, Carter EM, Raggio CL. Orthopedic considerations and surgical outcomes in Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet. 2021 Dec;187(4):458-465. doi: 10.1002/ajmg.c.31958. Epub 2021 Nov 29. PMID: 34845816. *Our results suggest that surgical outcomes are worse for individuals with EDS compared to the general population, a finding which is similar to other studies. Complications occurred more frequently in the EDS population than the average population"

Ehlers-Danlos Syndrome in Orthopaedics https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435946/pdf/10.1177_1941738112452385.pdf
Shirley ED, Demaio M, Bodurtha J. Ehlers-Danlos syndrome in orthopaedics: etiology, diagnosis, and treatment implications. Sports Health. 2012 Sep;4(5):394-403. doi: 10.1177/1941738112452385. PMID: 23016112; PMCID: PMC3435946. "Surgery may be associated with increased complications in patients with EDS relative to the general population."

Orthopaedic Management of the Ehlers-Danlos Syndromes https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajmg.c.31551
Ericson WB Jr, Wolman R. Orthopaedic management of the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet. 2017 Mar;175(1):188-194. doi: 10.1002/ajmg.c.31551. Epub 2017 Feb 13. PMID: 28192621. "Determining the correct and complete diagnoses in an EDS patient can be a difficult task, and the risks of all of the known hazards of surgical intervention are distinctly higher in EDS patients."

Surgical Recommendations in Hypermobile Ehlers-Danlos Syndrome https://webspace.clarkson.edu/~lrussek/docs/hypermobility/SurgeryHSD.pdf "Orthopedic surgeries in hEDS are more likely to have complications, with one study reporting 91% complication rate."

Orthopaedic Manifestations in Hypermobile Ehlers-Danlos Syndrome. https://journals.lww.com/jbjsjournal/abstract/9900/orthopaedic_manifestations_in_hypermobile.1511.aspx Eichinger, Josef K. MD, et al. The Journal of Bone and Joint Surgery ():10.2106/JBJS.24.01106, July 10, 2025. | DOI: 10.2106/JBJS.24.01106. "A total of 1,120 primary and 261 revision operations for joint or spine instability and/or pain were reported. The reported complication rates were 35.7% and 42.9% for joint and spine surgeries, respectively."